Some Symptoms:
- Progressive loss of hearing
- Carpel Tunnel Syndrome
- Stunted Growth
- Enlarged Internal Organs
- Claw-like Hands
- Delayed Development
- Vision Impairment
and many more
The enzyme that is missing is called iduronate sulfatase. In people without this disease, this enzyme is found in the lysosomes. It helps break down what are called glycosaminoglycans.
"Glycosaminoglycans are linear polysaccharides, whose disaccharide building blocks consist of an amino sugar (N-acetylglucosamine, glucosamine that is variously N-substituted, or N-acetylgalactosamine) and a uronic acid (glucuronic acid or iduronic acid) or galactose." - http://www.ncbi.nlm.nih.gov/books/NBK1900/
Without the enzyme, mucopolysaccharides build up. This causes damage to the connective tissues. This syndrome is also known as a lysosomal storage disease.
There are many risk factors that come along with this disease. It can take longer for someone to recover after an illness. Cardiovascular issues are prominent as well as skeletal issues. This disease can cause seizures and nervous system damage.
People obtain this disease from the carrying mother. It doesn't have many effective treatments, and is also progressive. It gets worse as time goes on. Since there is no exact cure for this disease, doctors tend to target the symptoms. This can help against an outburst. Gene therapy, enzyme therapy and bone marrow transplants are common treatments.